Sweet-Aide is one of three reward choices when completing Cacklespit's Brew quest, the other two being Inferior Boots and Even More Inferior Boots.
Notes[]
You can't use regular potions when the effect is active, so unless you have at least 304.5 hp regeneration per second or other ways to heal for the next 13.3 minutes (800 seconds), you will die if you drink this potion. Combining the effect of high regeneration and a combination of "Heal Self" and "Heal All" you may be able to avoid dying from drinking the potion.
Any +x% Potion Effectiveness will increase the Health loss.
As long as the potion is inside the player inventory upon entering the map and the player resets with "Quit to Main Menu", it can be used an unlimited number of times.
Drinking Sweet-Aide inside a town and respawning per "Quit to Main Menu" allows the player to discard any and all events that happened after entering said town, like enchanting, gambling and spending skill points. However, any changes to the Shared Stash are not reset. This allows a variety of exploits.
When farming bosses for eyes, you can make a save just before you are about to kill the boss. If the boss doesn't drop what you want, you can "Sweet-Aide" + "Quit to Main Menu" to reset the game to your last save, aka just before you killed the boss. Comparing to traditional farming, this is more efficient at "farming" a boss for eye, although you don't gain any extra XP or Fame like the normal farming would.